Ophthalmic Preparation BFS Aseptic Filling Equipment / BFS Eye Drops Manufacturing Machinery
The BFS is a dedicated state of the art system, enabling primary packaging of bulk pharmaceutical solutions into plastic containers of polypropylene or high density polyethylene or low density PE, using a Blow-Fill-Seal (BFS) technology.
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Extrusion of plastic granulate into a parison at high temperatures
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Blow-moulding of parison into a container with sterile-filtered air
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Filling of sterile-filtered solution
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Hermetic sealing of filled container
This filling unit assembly is composed of filling nozzles, the manifold with filling valves, the assembly for sterile air shower around the nozzles, the guide bars and the drive. In most cases it is possible to provide special cylinder drive for shifting the nozzles up and down. Such drive is compact and is particularly suitable for clean ambient. The absence of hydraulic cylinders offer safe and clean assembly right above the filling nozzles.
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Compliance: The design, MOC, manufacture, assembly and debugging meet the requirements of the new GMP standards for production.
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Performance: Advanced equipment with a unique, stable, and reliable structure.
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Efficiency: Integrated bottle making, filling, and capping reduces workshop area, energy consumption, and operating costs.
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Precision: Low-speed long-screw extruder driven by a servo motor reduces thermal stress and accurately controls bottle preforms.
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Smart Control: Each cycle is automatically compared and controlled with real-time feedback.
Frequently Asked Questions
What is BFS technology?
BFS stands for Blow-Fill-Seal. It is an advanced automated process where a plastic container is formed, filled, and sealed in one continuous aseptic operation.
What materials can be used for the bottles?
The machine is compatible with Polypropylene (PP), High-Density Polyethylene (HDPE), and Low-Density Polyethylene (LDPE).
What is the filling accuracy of this equipment?
The equipment provides high precision with a filling accuracy of ≤ ±1% to ±1.5% depending on the specific volume and medium.
Is the machine compliant with international standards?
Yes, the design and manufacturing of the BFS machine strictly adhere to cGMP and IEC electrical safety standards.
What container sizes can this BFS machine handle?
It can handle a wide range of specifications from 0.2ml up to 1000ml, with specific models optimized for 1ml to 50ml ophthalmic preparations.
How does the integrated structure save costs?
By combining bottle blowing, filling, and sealing into one machine, it reduces the required cleanroom area and lowers energy consumption for air conditioning.
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